1 Biochemistry and Toxicology Laboratory, Avicenne Military Hospital, Faculty of Medicine and Pharmacy, Cadi Ayyad University, Marrakech.
2 Department of Clinical Hematology, Avicenne Military Hospital, Faculty of Medicine and Pharmacy, Cadi Ayyad University, Marrakech.
GSC Advanced Research and Reviews, 2026, 27(02), 045-052
Article DOI: 10.30574/gscarr.2026.27.2.0107
Received on 25 March 2026; revised on 04 May 2026; accepted on 07 May 2026
Composite heterozygous sickle cell syndrome (SC) is a distinct entity, very different from homozygous sickle cell disease, characterized by less severe and less debilitating systemic disease. The milder clinical symptoms and subtle hematological abnormalities often lead to a delayed diagnosis in adulthood.
Hemoglobin electrophoresis and high-performance liquid chromatography remain highly useful and valuable methods for detecting hemoglobin abnormalities.
We report the case of a young patient with a dual hemoglobin variant (HbS and HbC) that was incidentally discovered during a routine workup.
Sickle Cell Syndromes; Hemoglobin Electrophoresis; HPLC; Detection of SC Heterozygosity
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Sara Elmalhi, Elhoussaine Rokni, Ismail Abouchoukre, Siham Ahchouch, Saliha Chellak and Abderrahman Boukhira. Incidental discovery of SC heterozygosity: A case report. GSC Advanced Research and Reviews, 2026, 27(02), 045-052. Article DOI: https://doi.org/10.30574/gscarr.2026.27.2.0107.