Preparation and in vitro evaluation of donepezil hydrochloride orodispersible tablets

Objective: The present study was aimed to prepare and evaluate Donepezil HCl Orodispersible tablets (DO-ODTs) using natural and synthetic superdisintegrants to increase patient compliance.

Methods: Direct compression was adapted using crospovidone, croscarmellose sodium as synthetic and mucilage isolated from fruits of Abelmoschus esculentus as natural superdisintegrants at different concentrations along with microcrystalline cellulose and aerosil. The powder mixture were subjected for pre and post compression evaluation including FTIR spectroscopy, micromeritic properties, tablet weight variation, hardness, friability, drug content, wetting time, dispersion time, water absorption ration, disintegration time and in vitro drug release.

Results: The low SD indicate the drug content was uniform, FTIR suggest no interaction between the drug and the excipients used. The DO-ODTs prepared with croscarmellose at higher concentration shows better in vitro drug release and relative properties than the DO-ODTs prepared with crospovidone and Abelmoschus esculentus. 

Conclusion: The results of this work reveals that DO-ODTs shows water absorption, dispersion, rapid disintegration time, fast drug release and good hardness, further conclude that DO-ODTs can be efficiently and successfully formulated by direct compression method.