Study on some enzymatic, hematologic and oxidative stress markers of leukemic variants

The requirements of additional insight on the knowledge of Leukemia were a driving impetus for this study. The expression of a myriad of circulating markers elucidates the pathological state in various types of Leukemia. Elevated oxidative stress with concomitant reduction in antioxidant factors are key indices having a nexus with Leukemic abnormalities. In this research we examined these markers in 100 participants in which 75 were Leukemic patients and 25 were normal subjects. The Leukemic subjects were further differentiated based on some parameters evaluated using spectrophotometric and microscopic methods. Results show a significant elevation of MDA in disease variants (all - b = 9.3 + 1.25; all - t = 9.88 + 0.87; aml = 9.2 + 1.57 nM/ml) as compared to the controls that gave (2.12 + 0.02 nM/ml); P 0.05). While there was a reduction in platelets and Vitamin E levels, there was marked increase in ESR and leucocyte count. These results are indicative of a stressed state in Leukemia. Knowledge of these biomarkers could enhance management efforts at confronting this disease condition.