Synthesis of heterocyclic and study activities in agriculture as anti-dubas on date palm trees via cholinesterase inhibitors

Thiazine derivatives, particularly chalcones, have garnered attention owing to their broad agricultural applications. This study aimed to synthesize chalcone derivatives and evaluate their insecticidal efficacy against Dubas bugs on date palm trees. In this study, we synthesized chalcone derivatives (A and B) via the condensation of p-substituted acetophenone and terephthalaldehyde in a basic medium. The compounds were characterized using 1H-NMR and FT-IR spectroscopy and evaluated for their insecticidal activity against Dubas bugs affecting date palm trees. Compound C, synthesized at a concentration of 7000 ppm, exhibited the highest efficacy in reducing dubas populations within the shortest time. Molecular studies revealed that all synthesized derivatives inhibited acetylcholinesterase (AChE), as confirmed by their interaction with the crystallographic structure of AChE (PDB ID:6xyu).