Differences of Mean Platelet Volume (MPV) value based on clinical stage of undifferentiated type nasopharyngeal carcinoma patient

Background: Nasopharyngeal carcinoma (NPC) is a head and neck malignancy that is endemic in southern China and Southeast Asia, including Indonesia. Biomarkers that are clinically proven in the prognosis of NPC therapy are still less effective. Measurement of the mean platelet volume (MPV) is a simple, inexpensive, useful, easy to apply test without additional costs. Increased MPV value can be a significant biomarker of head and neck malignancies as well as a warning of the risk of thrombosis in malignancy. Objective: to investigate the differences of mean platelet volume (MPV) value based on clinical stage of undifferentiated type nasopharyngeal carcinoma (NPC) patient. Methods: A cross-sectional study with 30 undifferentiated types of NPC patient. The sample was selected by systematic random sampling. The analysis used the ANOVA difference test to determine the difference in MPV values based on the clinical stage of the undifferentiated type of NPC patient. Results: The mean of MPV value was 12.40 with a standard deviation of 1.27. The highest distribution of undifferentiated types NPC patients based on the clinical stage, at stage III and IVA, with 12 patients (40%). The MPV values based on clinical stage in patients with undifferentiated type of NPC is significantly different with p = 0.012. Conclusion: In this study there was a significant difference between the MPV value based on the clinical stage of the undifferentiated type of NPC in ORL-HNS Outpatient, Ngoerah General Hospital with p = 0.012