A review on green tea catechins in Alzheimer’s disease of efficacy mechanism and future direction

Alzheimer’s disease (AD) is a complex neurodegenerative disorder with limited treatment options. Green tea rich in catechins has been investigated for its potential neuroprotective and cognitive – enhancing effect. Oxidative stress is a component of the pathological mechanisms underlying AD. It is caused by a disruption of the balance between reactive oxygen species and antioxidant molecules. This imbalance also causes neuroinflammation. Catechins, which are bioactive components of tea, have antioxidative and anti-inflammatory effects. Moreover, other potential properties related to AD prevention and modification have been reported in in vitro and in vivo studies. Several clinical studies have also been conducted to date. The current review summarizes recent updates and perspectives of the effects of catechins on AD based on the molecular mechanisms and related clinical studies. This review examine the current evidence on green tea efficacy, mechanism and future direction in AD management.