Early evolution of biochemical markers in severe and non-severe patients infected with Covid-19

Coronavirus disease 2019 (COVID-19) is an emerging infection that has caused a pandemic, it is due to a virus of the coronavirus family called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which can evolve into severe forms leading to death. Several biochemical alterations have been described in COVID-19 patients with great significance for clinical diagnosis and outcome prediction. The aim of this study is to compare early evolution of biochemical disturbances in COVID-19 patients and correlate them to severity of the disease.

This study was conducted in 70 COVID-19 patients hospitalized at the Avicenna military hospital. 20 patients in the medical intensive care unit (severe group) and 50 patients in the COVID-19 isolation hospital (non-severe group).

Across our laboratory data analysis of the two groups of COVID-19 patients, we demonstrated that high titles and early elevation of ferretinemia, Interleukin-6, High-Sensitivity Troponin T(us), NT-Pro-BNP, Blood Urea nitrogen, Creatinine and LDH are significantly correlated to severity of the disease.

The analysis of this study through the recent scientific literature demonstrates the interest of early monitoring of biochemical markers in the diagnosis of severity and monitoring of severe forms of covid-19.