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Development of simple, precise UV spectroscopic methods for the estimation of Lamotrigine in bulk and marketed tablet

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  • Development of Simple, Precise UV Spectroscopic Methods For The Estimation of Lamotrigine In Bulk and Marketed Tablet
  • Development of simple, precise UV spectroscopic methods for the estimation of Lamotrigine in bulk and marketed tablet

Syed Hafeez Pasha Qhadri 1, Yegnoor Anand Kumar 2, *, Neeladri Srinivasulu 1, Aayush Nahar 1 and Avanish Srivastav 1

1 Department of Pharmaceutical Chemistry, V. L. College of Pharmacy, Raichur-548103, Karnataka, India.
2 Department of Pharmaceutics, V. L. College of Pharmacy, Raichur-548103, Karnataka, India.
 
Research Article
GSC Advanced Research and Reviews, 2022, 13(01), 200–209.
Article DOI: 10.30574/gscarr.2022.13.1.0284
DOI url: https://doi.org/10.30574/gscarr.2022.13.1.0284
Received on 18 September 2022; revised on 22 October 2022; accepted on 25 October 2022
Two Simple and precise UV spectroscopic methods were developed for the estimation of lamotrigine in bulk and marketed tablets. The methods developed by using two solvent systems viz., Acetonitrile: Distilled water (1:1) and Methanol: 0.1N HCl (3:1) were validated as per ICH guidelines. The two proposed solvent systems validated for linearity, accuracy, precision, robustness, ruggedness and solution stability. The percent recovery in the marketed tablet formulation was found to be good agreement with the label claim. The methods validated statistically and the results suggest these methods can employed for the routine analysis of lamotrigine in bulk and marketed tablet formulations.
Lamotrigine; UV spectroscopy; Validation; Accuracy; Precision
 
https://gscarr.gsconlinepress.com/sites/default/files/fulltext_pdf/GSCARR-2022-…

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Syed Hafeez Pasha Qhadri, Yegnoor Anand Kumar, Neeladri Srinivasulu, Aayush Nahar and Avanish Srivastav. Development of simple, precise UV spectroscopic methods for the estimation of Lamotrigine in bulk and marketed tablet. GSC Advanced Research and Reviews, 2022, 13(1), 200-209. Article DOI: https://doi.org/10.30574/gscarr.2022.13.1.0284

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