1 Dept. of Veterinary Hygiene and Environmental Pollution, Faculty of Veterinary Medicine, Cairo University, Egypt.
2 Researcher in Dept. of Pharmaceuticals Biotechnology, Martin Luther King College, Germany. Email.
3 Researcher in Dept. of Hygiene and Environmental Pollution, Faculty of Veterinary Medicine, Cairo University, Egypt.
Research Article
GSC Advanced Research and Reviews, 2020, 04(01), 069-077.
Article DOI: 10.30574/gscarr.2020.4.1.0060
Received on 13 July 2020; revised on 29 July 2020; accepted on 30 July 2020
In the present study, brain damages, serotonin and nor-epinephrine activity on rat brain were investigated. A single sub-acute lethal -oral dose of Alpha-Cypermethrin (25 mg kg -1) was given to rat. Blood and brain tissue samples were examined biologically and histopathologically at various times (1, 2, 3, 4 and24 h) after dosing. Results revealed that extracellular serotonin levels % (f mol/mg tissue) in rat ventral hippocampus at 25 mg kg-1 B.W. After 1, 2, 3 and 24 hr. were 105±4, 80 ±7, 80 ±4, 70 ±4, respectively. While extracellular NA levels after 1, 2, 3 and 24 hr. were 300±10, 450 ±14, 400±12, 400±11, respectively. Alpha-cypermethrin acts as nor-epinephrine reuptake inhibitors (NRIs) and serotonin reuptake stimulator in rat brain. The lesions in the brain of the treated groups were gliosis, perineuronal vacuolation, perivascular vacuolation, and neuronal degeneration.
Brain Damage; Alpha-Cypermethrin; Acute Sub-Lethal Dose; Serotonin; Nor-epinephrine.
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Kaoud Hussein A, Elsaied Ahmed H and Khalil Maged A. Effect of alpha-cypermethrin on serotonin, nor-epinephrine and brain changes in rats. GSC Advanced Research and Reviews, 2020, 4(1), 069-077. Article DOI: https://doi.org/10.30574/gscarr.2020.4.1.0060