1 Study Program of Chemistry, Faculty of Mathematics and Natural Sciences, Mulawarman University, Jalan barong Tongkok No.4, Samarinda-75119, Indonesia.
2 College of Industrial and Pharmaceutical Technology (STTIF), Bogor-16151, Indonesia.
3 Research Center for Pharmaceutical Ingredient and Traditional Medicinal, National Research and Innovation Agency (BRIN); KST Soekarno, Cibinong 16911, Indonesia.
4 Faculty of Pharmacy, Pancasila University, Srengseng sawah, Jagakarsa, Jakarta Selatan-12640, Indonesia.
Research Article
GSC Advanced Research and Reviews, 2023, 17(02), 240–246
Article DOI: 10.30574/gscarr.2023.17.2.0446
Received on 12 October 2023; revised on 25 November 2023; accepted on 28 November 2023
Isolation and identification of one chemical compound from the seeds of soursop, Annona muricata (Annonaceae) based on bioactivity-guided fractionation by the Brine Shrimp Lethality Assay (BSLA) have been done. The powder of soursop seed was extracted successively with n-hexane, chloroform, and methanol then the methanol extract was partitioned with ethylacetate water. Isolation and purification of ethylacetate extracts were carried out by column chromatography [(SiO2; i. n-hexane-chloroform = 15:1 ~ 1:1 gave one pure isolatedcompound. Based on Ultra Violet (UV), Infra-Red (IR), Nuclear Magnetic Resonance (NMR), and mass spectra (LC-MS/MS), the isolated Fr-4 was an acetogenin compound, sabadelin which had a weak cytotoxicity LC50 of 487 ppm.
Annona muricata; Acetogenin; Sabadelin; Cytotoxic; Brine Shrimp Lethality Test
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RUDI KARTIKA, LILIK SULASTRI, ANDI SAPTAJI KAMAL, ELSERA BR TARIGAN and PARTOMUAN SIMANJUNTAK. Identification of acetogenin compound, sabadelin from soursop seeds, Annona muricata (Annonaceae). GSC Advanced Research and Reviews, 2023, 17(2), 240-246. Article DOI: https://doi.org/10.30574/gscarr.2023.17.2.0446